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Department of Molecular Mechanisms of Disease

Publications - Prof. Dr. Michael O. Hottiger

Full list of publications

Most recent publications

Muskalla L, Güldenpfennig A, Hottiger MO

Subcellular Quantitation of ADP-Ribosylation by High-Content Microscopy

Methods Mol Biol. 2023;2609:101-109. doi: 10.1007/978-1-0716-2891-1_7. PMID: 36515832.

 

Schraml P, Aimi F, Zoche M, Aguilera-Garcia D, Arnold F, Moch H, Hottiger MO

Altered cytoplasmic and nuclear ADP-ribosylation levels analyzed with an improved ADP-ribose binder are a prognostic factor in renal cell carcinoma

J Pathol Clin Res. 2023 Mar 31. doi: 10.1002/cjp2.320. Epub ahead of print. PMID: 36999983.

 

Lüscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, Cohen M, Corda D, Dantzer F, Daugherty MD, Dawson TM, Dawson VL, Deindl S, Fehr AR, Feijs KLH, Filippov DV, Gagné JP, Grimaldi G, Guettler S, Hoch NC, Hottiger MO, Korn P, Kraus WL, Ladurner A, Lehtiö L, Leung AKL, Lord CJ, Mangerich A, Matic I, Matthews J, Moldovan GL, Moss J, Natoli G, Nielsen ML, Niepel M, Nolte F, Pascal J, Paschal BM, Pawłowski K, Poirier GG, Smith S, Timinszky G, Wang ZQ, Yélamos J, Yu X, Zaja R, Ziegler M

ADP-ribosyltransferases, an update on function and nomenclature

FEBS J. 2022 Dec;289(23):7399-7410. doi: 10.1111/febs.16142. Epub 2021 Sep 13. PMID: 34323016; PMCID: PMC9027952.

 

Liu L, Sandow JJ, Leslie Pedrioli DM, Samson AL, Silke N, Kratina T, Ambrose RL, Doerflinger M, Hu Z, Morrish E, Chau D, Kueh AJ, Fitzibbon C, Pellegrini M, Pearson JS, Hottiger MO, Webb AI, Lalaoui N, Silke J

Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death

Sci Adv. 2022 May 13;8(19):eabh2332. doi: 10.1126/sciadv.abh2332. Epub 2022 May 11. PMID: 35544574; PMCID: PMC9094663.

 

Kuraoka S, Higashi H, Yanagihara Y, Sonawane AR, Mukai S, Mlynarchik AK, Whelan MC, Hottiger MO, Nasir W, Delanghe B, Aikawa M, Singh SA

A Novel Spectral Annotation Strategy Streamlines Reporting of Mono-ADP-ribosylated Peptides Derived from Mouse Liver and Spleen in Response to IFN-γ

Mol Cell Proteomics. 2022 Apr;21(4):100153. doi: 10.1016/j.mcpro.2021.100153. Epub 2021 Sep 28. PMID: 34592425; PMCID: PMC9014395.

 

Boehi F, Manetsch P, Hottiger MO

Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses

Cell Discov. 2021 Nov 2;7(1):104. doi: 10.1038/s41421-021-00323-9. PMID: 34725336; PMCID: PMC8560908.

 

Aimi F, Moch H, Schraml P, Hottiger MO

Cytoplasmic ADP-ribosylation levels correlate with markers of patient outcome in distinct human cancers

Mod Pathol. 2021 Aug;34(8):1468-1477. doi: 10.1038/s41379-021-00788-9. Epub 2021 Mar 19. PMID: 33742140; PMCID: PMC8295037.

 

Leutert M, Duan Y, Winzer R, Menzel S, Tolosa E, Magnus T, Hottiger MO, Koch-Nolte F, Rissiek B

Identification of the Mouse T Cell ADP-Ribosylome Uncovers ARTC2.2 Mediated Regulation of CD73 by ADP-Ribosylation

Front Immunol. 2021 Aug 24;12:703719. doi: 10.3389/fimmu.2021.703719. PMID: 34504490; PMCID: PMC8421852.

 

Hopp AK, Hottiger MO

Investigation of Mitochondrial ADP-Ribosylation Via Immunofluorescence

Methods Mol Biol. 2021;2276:165-171. doi: 10.1007/978-1-0716-1266-8_12. PMID: 34060040.

 

Lüthi SC, Howald A, Nowak K, Graage R, Bartolomei G, Neupert C, Sidler X, Leslie Pedrioli D, Hottiger MO

Establishment of a Mass-Spectrometry-Based Method for the Identification of the In Vivo Whole Blood and Plasma ADP-Ribosylomes

J Proteome Res. 2021 Jun 4;20(6):3090-3101. doi: 10.1021/acs.jproteome.0c00923. Epub 2021 May 25. PMID: 34032442.

 

Bisceglie L, Hopp AK, Gunasekera K, Wright RH, Le Dily F, Vidal E, Dall'Agnese A, Caputo L, Nicoletti C, Puri PL, Beato M, Hottiger MO

MyoD induces ARTD1 and nucleoplasmic poly-ADP-ribosylation during fibroblast to myoblast transdifferentiation

iScience. 2021 Apr 17;24(5):102432. doi: 10.1016/j.isci.2021.102432. PMID: 33997706; PMCID: PMC8102911.

 

Hopp AK, Hottiger MO

Uncovering the Invisible: Mono-ADP-ribosylation Moved into the Spotlight

Cells. 2021 Mar 19;10(3):680. doi: 10.3390/cells10030680. PMID: 33808662; PMCID: PMC8003356.

 

Hopp AK, Teloni F, Bisceglie L, Gondrand C, Raith F, Nowak K, Muskalla L, Howald A, Pedrioli PGA, Johnsson K, Altmeyer M, Pedrioli DML, Hottiger MO

Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation

Mol Cell. 2021 Jan 21;81(2):340-354.e5. doi: 10.1016/j.molcel.2020.12.034. Epub 2021 Jan 14. PMID: 33450210; PMCID: PMC7837215.

 

Gehrig PM, Nowak K, Panse C, Leutert M, Grossmann J, Schlapbach R, Hottiger MO

Gas-Phase Fragmentation of ADP-Ribosylated Peptides: Arginine-Specific Side-Chain Losses and Their Implication in Database Searches

J Am Soc Mass Spectrom. 2021 Jan 6;32(1):157-168. doi: 10.1021/jasms.0c00040. Epub 2020 Nov 3. PMID: 33140951.

 

Glaus Garzon JF, Pastrello C, Jurisica I, Hottiger MO, Wenger RH, Borsig L

Tumor cell endogenous HIF-1α activity induces aberrant angiogenesis and interacts with TRAF6 pathway required for colorectal cancer development

Neoplasia. 2020 Dec;22(12):745-758. doi: 10.1016/j.neo.2020.10.006. Epub 2020 Oct 24. PMID: 33142239; PMCID: PMC7588814.

 

Cheng D, Gao G, Di Lorenzo A, Jayne S, Hottiger MO, Richard S, Bedford MT

Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6

J Biol Chem. 2020 Dec 11;295(50):17060-17070. doi: 10.1074/jbc.RA120.014704. Epub 2020 Oct 2. PMID: 33008887; PMCID: PMC7863876.

 

Niu Y, Yang L, Gao T, Dong C, Zhang B, Yin P, Hopp AK, Li D, Gan R, Wang H, Liu X, Cao X, Xie Y, Meng X, Deng H, Zhang X, Ren J, Hottiger MO, Chen Z, Zhang Y, Liu X, Feng Y

A Type I-F Anti-CRISPR Protein Inhibits the CRISPR-Cas Surveillance Complex by ADP-Ribosylation

Mol Cell. 2020 Nov 5;80(3):512-524.e5. doi: 10.1016/j.molcel.2020.09.015. Epub 2020 Oct 12. PMID: 33049228.

 

Nowak K, Rosenthal F, Karlberg T, Bütepage M, Thorsell AG, Dreier B, Grossmann J, Sobek J, Imhof R, Lüscher B, Schüler H, Plückthun A, Leslie Pedrioli DM, Hottiger MO

Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins

Nat Commun. 2020 Oct 15;11(1):5199. doi: 10.1038/s41467-020-18981-w. PMID: 33060572; PMCID: PMC7566600

 

Vdovenko D, Bachmann M, Wijnen WJ, Hottiger MO, Eriksson U, Valaperti A

The adaptor protein c-Cbl-associated protein (CAP) limits pro-inflammatory cytokine expression by inhibiting the NF-κB pathway

Int Immunopharmacol. 2020 Oct;87:106822. doi: 10.1016/j.intimp.2020.106822. Epub 2020 Jul 29. PMID: 32738595.

 

Ashok Y, Miettinen M, Oliveira DKH, Tamirat MZ, Näreoja K, Tiwari A, Hottiger MO, Johnson MS, Lehtiö L, Pulliainen AT

Discovery of Compounds Inhibiting the ADP-Ribosyltransferase Activity of Pertussis Toxin

ACS Infect Dis. 2020 Apr 10;6(4):588-602. doi: 10.1021/acsinfecdis.9b00412. Epub 2020 Jan 13. PMID: 31899865.

 

Wang C, Xiao J, Nowak K, Gunasekera K, Alippe Y, Speckman S, Yang T, Kress D, Abu-Amer Y, Hottiger MO, Mbalaviele G

PARP1 Hinders Histone H2B Occupancy at the NFATc1 Promoter to Restrain Osteoclast Differentiation

J Bone Miner Res. 2020 Apr;35(4):776-788. doi: 10.1002/jbmr.3927. Epub 2020 Jan 7. PMID: 31793068; PMCID: PMC7465553.

 

Arsiwala T, Pahla J, van Tits LJ, Bisceglie L, Gaul DS, Costantino S, Miranda MX, Nussbaum K, Stivala S, Blyszczuk P, Weber J, Tailleux A, Stein S, Paneni F, Beer JH, Greter M, Becher B, Mostoslavsky R, Eriksson U, Staels B, Auwerx J, Hottiger MO, Lüscher TF, Matter CM

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1

J Mol Cell Cardiol. 2020 Feb;139:24-32. doi: 10.1016/j.yjmcc.2020.01.002. Epub 2020 Jan 21. PMID: 31972266.

 

Hopp AK, Grüter P, Hottiger MO

Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation

Cells. 2019 Aug 13;8(8):890. doi: 10.3390/cells8080890. Erratum in: Cells. 2019 Oct 31;8(11): PMID: 31412683; PMCID: PMC6721828.

 

Xu Y, Zhou P, Cheng S, Lu Q, Nowak K, Hopp AK, Li L, Shi X, Zhou Z, Gao W, Li D, He H, Liu X, Ding J, Hottiger MO, Shao F

A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy

Cell. 2019 Jul 25;178(3):552-566.e20. doi: 10.1016/j.cell.2019.06.007

 

Higashi H, Maejima T, Lee LH, Yamazaki Y, Hottiger MO, Singh SA, Aikawa M

A Study into the ADP-Ribosylome of IFN-γ-Stimulated THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-Ribosylation

J Proteome Res. 2019 Mar 21. doi:0.1021/acs.jproteome.8b00895

 

Kunze FA, Bauer M, Komuczki J, Lanzinger M, Gunasekera K, Hopp AK, Lehmann M, Becher B, Müller A, Hottiger MO

ARTD1 in Myeloid Cells Controls the IL-12/18-IFN-γ Axis in a Model of Sterile Sepsis, Chronic Bacterial Infection, and Cancer

J Immunol. 2019 Jan 23. pii: ji1801107. doi: 10.4049/jimmunol.1801107

 

Lopez-Garcia LA, Demiray L, Ruch-Marder S, Hopp AK, Hottiger MO, Helbling PM, Pavlou MP

Validation of extracellular ligand-receptor interactions by Flow-TriCEPS

BMC Res Notes. 2018 Dec 5;11(1):863. doi: 10.1186/s13104-018-3974-5

 

Tugues S, Amorim A, Spath S, Martin-Blondel G, Schreiner B, De Feo D, Lutz M, Guscetti F, Apostolova P, Haftmann C, Hasselblatt P, Núñez NG, Hottiger MO, van den Broek M, Manz MG, Zeiser R, Becher B

Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid cells​​​

Sci Transl Med. 2018 Nov 28;10(469). pii: eaat8410. doi: 10.1126/scitranslmed.aat8410

 

Leutert M, Menzel S, Braren R, Rissiek B, Hopp A, Nowak K, Bisceglie L, Gehrig P, Li H, Zolkiewska A, Koch-Nolte F, Hottiger MO

Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme

Cell Rep. 2018 Aug 14;24(7):1916-1929.e5. doi: 10.1016/j.celrep.2018.07.048

 

Abplanalp J, Hopp AK, Hottiger MO

Mono-ADP-Ribosylhydrolase Assays

Methods Mol Biol. 2018;1813:205-213. doi: 10.1007/978-1-4939-8588-3_13

 

Leslie Pedrioli DM, Leutert M, Bilan V, Nowak K, Gunasekera K, Ferrari E, Imhof R, Malmström L, Hottiger MO

Comprehensive ADP-ribosylome analysis identifies tyrosine as an ADP-ribose acceptor site

EMBO Rep. 2018 Jun 28. pii: e45310

 

Abplanalp J, Leutert M, Frugier E, Nowak K, Feurer R, Kato J, Kistemaker HVA, Filippov DV, Moss J, Caflisch A, Hottiger MO

Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase

Nat Commun. 2017 Dec 12;8(1):2055

 

Rissiek B, Menzel S, Leutert M, Cordes M, Behr S, Jank L, Ludewig P, Gelderblom M, Rissiek A, Adriouch S, Haag F, Hottiger MO, Koch-Nolte F, Magnus T

Ecto-ADP-ribosyltransferase ARTC2.1 functionally modulates FcγR1 and FcγR2B on murine microglia

Sci Rep. 2017 Nov 28;7(1):16477

 

Bisceglie L, Bartolomei G, Hottiger MO

ADP-ribose-specific chromatin-affinity purification for investigating genome-wide or locus-specific chromatin ADP-ribosylation

Nat Protoc. 2017 Sep;12(9):1951-1961

 

Larsen SC, Leutert M, Bilan V, Martello R, Jungmichel S, Young C, Hottiger MO, Nielsen ML

Proteome-Wide Identification of In Vivo ADP-Ribose Acceptor Sites by Liquid Chromatography-Tandem Mass Spectrometry

Methods Mol Biol. 2017;1608:149-162

 

Leutert M, Bilan V, Gehrig P, Hottiger MO

Identification of ADP-Ribose Acceptor Sites on In Vitro Modified Proteins by Liquid Chromatography-Tandem Mass Spectrometry

Methods Mol Biol. 2017;1608:137-148

 

Bilan V, Selevsek N, Kistemaker HA, Abplanalp J, Feurer R, Filippov DV & Hottiger MO

New quantitative mass spectrometry approaches reveal different ADP-ribosylation phases dependent on the levels of oxidative stress

Mol. Cell. Proteomics 16(5):949 (2017)

 

Robaszkiewicz A, Qu C, Wisnik E, Ploszaj T, Mirsaidi A, Kunze FA, Richards PJ, Cinelli P, Mbalaviele G, Hottiger MO

ARTD1 regulates osteoclastogenesis and bone homeostasis by dampening NF-κB-dependent transcription of IL-1β

Sci Rep. 2016 Feb 17;6:21131

 

Bartolomei G, Leutert M, Manzo M, Baubec T, Hottiger MO

Analysis of Chromatin ADP-Ribosylation at the Genome-wide Level and at Specific Loci by ADPr-ChAP

Mol Cell. 2016 Feb 4;61(3):474-85

Highlighted in ADPr-ChAP: Mapping ADP-Ribosylation onto the Genome. Mol Cell. 2016;61(3):327-8

 

Andersson A, Bluwstein A, Kumar N, Teloni F, Traenkle J, Baudis M, Altmeyer M & Hottiger MO

PKCalpha and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation

Nucleic Acids Res. 44(16):7630 (2016)

 

Rosenthal F, Nanni P, Barkow-Oesterreicher S, Hottiger MO

Optimization of LTQ-Orbitrap Mass Spectrometer Parameters for the Identification of ADP-Ribosylation Sites

J Proteome Res. 2015 Sep 4;14(9):4072-9

 

Lehmann M, Pirinen E, Mirsaidi A, Kunze FA, Richards PJ, Auwerx J, Hottiger MO

ARTD1-induced poly-ADP-ribose formation enhances PPARγ ligand binding and co-factor exchange

Nucleic Acids Res. 2015 Jan;43(1):129-42

 

Weber FA, Bartolomei G, Hottiger MO, Cinelli P

Artd1/Parp1 regulates reprogramming by transcriptional regulation of Fgf4 via Sox2 ADP-ribosylation

Stem Cells. 2013 Nov;31(11):2364-73

 

Jungmichel S, Rosenthal F, Altmeyer M, Lukas J, Hottiger MO, Nielsen ML

Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses

Mol Cell. 2013 Oct 24;52(2):272-85

 

Kassner I, Barandun M, Fey M, Rosenthal F, Hottiger MO

Crosstalk between SET7/9-dependent methylation and ARTD1-mediated ADP-ribosylation of histone H1.4

Epigenetics Chromatin. 2013 Jan 5;6(1):1

 

Rosenthal F, Feijs KL, Frugier E, Bonalli M, Forst AH, Imhof R, Winkler HC, Fischer D, Caflisch A, Hassa PO, Lüscher B, Hottiger MO

Macrodomain-containing proteins are novel mono-ADP-ribosylhydrolases

Nat Struct Mol Biol 2013;20(4):502-7

Highlighted in Expanding the functional repertoire of macrodomains. Nat Struct Mol Biol 2013;20(4):407

 

Erener S, Pétrilli V, Kassner I, Minotti R, Castillo R, Santoro R, Hassa PO, Tschopp J, Hottiger M

Inflammasome-Activated Caspase 7 Cleaves PARP1 to Enhance the Expression of a Subset of NF-κB Target Genes

Mol Cell 2012 Apr 27;46(2):200-11

 

Messner S, Altmeyer M, Zhao H, Pozivil A, Roschitzki B, Gehrig P, Rutishauser D, Huang D, Caflisch A, Hottiger MO

PARP1 ADP-ribosylates lysine residues of the core histone tails

Nucleic Acids Res 2010;38(19):6350-6362

 

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