Publications - Prof. Dr. Michael O. Hottiger

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Featured publications

Bacterial effector

 

Xu Y, Zhou P, Cheng S, Lu Q, Nowak K, Hopp AK, Li L, Shi X, Zhou Z, Gao W, Li D, He H, Liu X, Ding J, Hottiger MO, Shao F
A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates XenophagyCell. 2019 Jul 25;178(3):552-566.e20. doi: 10.1016/j.cell.2019.06.007

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ARTD1

 

Higashi H, Maejima T, Lee LH, Yamazaki Y, Hottiger MO, Singh SA, Aikawa M
A Study into the ADP-Ribosylome of IFN-γ-Stimulated THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-Ribosylation
J Proteome Res. 2019 Mar 21. doi:0.1021/acs.jproteome.8b00895

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Kunze JI

 

Kunze FA, Bauer M, Komuczki J, Lanzinger M, Gunasekera K, Hopp AK, Lehmann M, Becher B, Müller A, Hottiger MO
ARTD1 in Myeloid Cells Controls the IL-12/18-IFN-γ Axis in a Model of Sterile Sepsis, Chronic Bacterial Infection, and Cancer
J Immunol. 2019 Jan 23. pii: ji1801107. doi: 10.4049/jimmunol.1801107

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Abstract Lopez_Hottiger

 

Lopez-Garcia LA, Demiray L, Ruch-Marder S, Hopp AK, Hottiger MO, Helbling PM, Pavlou MP
Validation of extracellular ligand-receptor interactions by Flow-TriCEPS
BMC Res Notes. 2018 Dec 5;11(1):863. doi: 10.1186/s13104-018-3974-5

PubMed

Tugues et al

 

Tugues S, Amorim A, Spath S, Martin-Blondel G, Schreiner B, De Feo D, Lutz M, Guscetti F, Apostolova P, Haftmann C, Hasselblatt P, Núñez NG, Hottiger MO, van den Broek M, Manz MG, Zeiser R, Becher B
Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid cells​​​
Sci Transl Med. 2018 Nov 28;10(469). pii: eaat8410. doi: 10.1126/scitranslmed.aat8410

PubMed

Proteomic Characterization

 

Leutert M, Menzel S, Braren R, Rissiek B, Hopp A, Nowak K, Bisceglie L, Gehrig P, Li H, Zolkiewska A, Koch-Nolte F, Hottiger MO
Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme
Cell Rep. 2018 Aug 14;24(7):1916-1929.e5. doi: 10.1016/j.celrep.2018.07.048

PubMed

MMB Abplanalp

 

Abplanalp J, Hopp AK, Hottiger MO
Mono-ADP-Ribosylhydrolase Assays
Methods Mol Biol. 2018;1813:205-213. doi: 10.1007/978-1-4939-8588-3_13

PubMed

Comprehensive ADP ribsylome

 

Leslie Pedrioli DM, Leutert M, Bilan V, Nowak K, Gunasekera K, Ferrari E, Imhof R, Malmström L, Hottiger MO
Comprehensive ADP-ribosylome analysis identifies tyrosine as an ADP-ribose acceptor site
EMBO Rep. 2018 Jun 28. pii: e45310

PubMed

Proteomic analyses

 

Abplanalp J, Leutert M, Frugier E, Nowak K, Feurer R, Kato J, Kistemaker HVA, Filippov DV, Moss J, Caflisch A, Hottiger MO
Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase
Nat Commun. 2017 Dec 12;8(1):2055

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Ecto ADP ribosyltransferase

 

Rissiek B, Menzel S, Leutert M, Cordes M, Behr S, Jank L, Ludewig P, Gelderblom M, Rissiek A, Adriouch S, Haag F, Hottiger MO, Koch-Nolte F, Magnus T
Ecto-ADP-ribosyltransferase ARTC2.1 functionally modulates FcγR1 and FcγR2B on murine microglia
Sci Rep. 2017 Nov 28;7(1):16477

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ADP ribose specific chromatin

 

Bisceglie L, Bartolomei G, Hottiger MO
ADP-ribose-specific chromatin-affinity purification for investigating genome-wide or locus-specific chromatin ADP-ribosylation
Nat Protoc. 2017 Sep;12(9):1951-1961

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Proteome Wide Identification

 

Larsen SC, Leutert M, Bilan V, Martello R, Jungmichel S, Young C, Hottiger MO, Nielsen ML
Proteome-Wide Identification of In Vivo ADP-Ribose Acceptor Sites by Liquid Chromatography-Tandem Mass Spectrometry
Methods Mol Biol. 2017;1608:149-162

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Identification of ADP Ribose

 

Leutert M, Bilan V, Gehrig P, Hottiger MO
Identification of ADP-Ribose Acceptor Sites on In Vitro Modified Proteins by Liquid Chromatography-Tandem Mass Spectrometry
Methods Mol Biol. 2017;1608:137-148

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New quantitative mass

Bilan V, Selevsek N, Kistemaker HA, Abplanalp J, Feurer R, Filippov DV & Hottiger MO
New quantitative mass spectrometry approaches reveal different ADP-ribosylation phases dependent on the levels of oxidative stress
Mol. Cell. Proteomics 16(5):949 (2017)

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Graphical abstract

Bartolomei G, Leutert M, Manzo M, Baubec T, Hottiger MO
Analysis of Chromatin ADP-Ribosylation at the Genome-wide Level and at Specific Loci by ADPr-ChAP
Mol Cell. 2016 Feb 4;61(3):474-85

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Highlighted in ADPr-ChAP: Mapping ADP-Ribosylation onto the Genome. Mol Cell. 2016;61(3):327-8

Graphical abstract SREP 2016

Andersson A, Bluwstein A, Kumar N, Teloni F, Traenkle J, Baudis M, Altmeyer M & Hottiger MO
PKCalpha and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation
Nucleic Acids Res. 44(16):7630 (2016)
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Rosenthal F, Feijs KL, Frugier E, Bonalli M, Forst AH, Imhof R, Winkler HC, Fischer D, Caflisch A, Hassa PO, Lüscher B, Hottiger MO
Macrodomain-containing proteins are novel mono-ADP-ribosylhydrolases
Nat Struct Mol Biol 2013;20(4):502-7

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Highlighted in Expanding the functional repertoire of macrodomains. Nat Struct Mol Biol 2013;20(4):407

Erener S, Pétrilli V, Kassner I, Minotti R, Castillo R, Santoro R, Hassa PO, Tschopp J, Hottiger M
Inflammasome-Activated Caspase 7 Cleaves PARP1 to Enhance the Expression of a Subset of NF-κB Target Genes
Mol Cell 2012 Apr 27;46(2):200-11

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Graphical abstract SREP 2016

Robaszkiewicz A, Qu C, Wisnik E, Ploszaj T, Mirsaidi A, Kunze FA, Richards PJ, Cinelli P, Mbalaviele G, Hottiger MO
ARTD1 regulates osteoclastogenesis and bone homeostasis by dampening NF-κB-dependent transcription of IL-1β
Sci Rep. 2016 Feb 17;6:21131

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Graphical abstract JPR 2016

Rosenthal F, Nanni P, Barkow-Oesterreicher S, Hottiger MO
Optimization of LTQ-Orbitrap Mass Spectrometer Parameters for the Identification of ADP-Ribosylation Sites
J Proteome Res. 2015 Sep 4;14(9):4072-9

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graphical-abstract-nar-lehmann-2015

Lehmann M, Pirinen E, Mirsaidi A, Kunze FA, Richards PJ, Auwerx J, Hottiger MO
ARTD1-induced poly-ADP-ribose formation enhances PPARγ ligand binding and co-factor exchange
Nucleic Acids Res. 2015 Jan;43(1):129-42

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Weber FA, Bartolomei G, Hottiger MO, Cinelli P
Artd1/Parp1 regulates reprogramming by transcriptional regulation of Fgf4 via Sox2 ADP-ribosylation
Stem Cells. 2013 Nov;31(11):2364-73

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Graphical abstract Jungmichel

Jungmichel S, Rosenthal F, Altmeyer M, Lukas J, Hottiger MO, Nielsen ML
Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses
Mol Cell. 2013 Oct 24;52(2):272-85

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Kassner model

Kassner I, Barandun M, Fey M, Rosenthal F, Hottiger MO
Crosstalk between SET7/9-dependent methylation and ARTD1-mediated ADP-ribosylation of histone H1.4
Epigenetics Chromatin. 2013 Jan 5;6(1):1

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Messner S, Altmeyer M, Zhao H, Pozivil A, Roschitzki B, Gehrig P, Rutishauser D, Huang D, Caflisch A, Hottiger MO
PARP1 ADP-ribosylates lysine residues of the core histone tails
Nucleic Acids Res 2010;38(19):6350-6362

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