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Department of Molecular Mechanisms of Disease

Publications - Prof. Dr. Matthias Altmeyer

Full list of publications

Spegg V, Altmeyer M

Genome maintenance meets mechanobiology

Chromosoma. 2023 Aug 15



Nina Schmolka, Ino D Karemaker, Richard Cardoso da Silva, Davide C Recchia, Vincent Spegg, Jahnavi Bhaskaran, Michael Teske, Nathalie P de Wagenaar, Matthias Altmeyer, Tuncay Baubec

Dissecting the roles of MBD2 isoforms and domains in regulating NuRD complex function during cellular differentiation

Nat Commun. 2023 Jun 29;14(1):3848.


Aswini Krishnan, Vincent Spegg, Susanne Dettwiler, Peter Schraml, Holger Moch, Konstantin Dedes, Zsuzsanna Varga, Matthias Altmeyer

Analysis of the PARP1, ADP-Ribosylation, and TRIP12 Triad With Markers of Patient Outcome in Human Breast Cancer

Mod Pathol. 2023 Mar 27;36(7):100167.


Vincent Spegg, Andreas Panagopoulos, Merula Stout, Aswini Krishnan, Giordano Reginato, Ralph Imhof, Bernd Roschitzki, Petr Cejka, Matthias Altmeyer

Phase separation properties of RPA combine high-affinity ssDNA binding with dynamic condensate functions at telomeres

Nat Struct Mol Biol. 2023 Apr;30(4):451-462.


Thorsten Mosler, H Irem Baymaz, Justus F Gräf, Ivan Mikicic, Georges Blattner, Edward Bartlett, Matthias Ostermaier, Rossana Piccinno, Jiwen Yang, Andrea Voigt, Marco Gatti, Stefania Pellegrino, Matthias Altmeyer, Katja Luck, Ivan Ahel, Vassilis Roukos, Petra Beli

PARP1 proximity proteomics reveals interaction partners at stressed replication forks

Nucleic Acids Res. 2022 Nov 11;50(20):11600-11618.


Singh JK, Noordermeer SM, Jimenez-Sainz J, Maranon DG, Altmeyer M

Editorial: Protecting the code: DNA double-strand break repair pathway choice

Front Genet. 2022 Aug 12;13:993889.


Groelly FJ, Dagg RA, Petropoulos M, Rossetti GG, Prasad B, Panagopoulos A, Paulsen T, Karamichali A, Jones SE, Ochs F, Dionellis VS, Puig Lombardi E, Miossec MJ, Lockstone H, Legub e G, Blackford AN, Altmeyer M, Halazonetis TD, Tarsounas M

Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells

Mol Cell. 2022 Aug 17:S1097-2765(22)00707-9.


Bolck HA, Przetocka S, Meier R, von Aesch C, Zurfluh C, Hänggi K, Spegg V, Altmeyer M, Stebler M, Nørrelykke SF, Horvath P, Sartori AA, Porro A

RNAi Screening Uncovers a Synthetic Sick Interaction between CtIP and the BARD1 Tumor Suppressor

Cells. 2022 Feb 12;11(4):643.


Balbo Pogliano C, Ceppi I, Giovannini S, Petroulaki V, Palmer N, Uliana F, Gatti M, Kasaciunaite K, Freire R, Seidel R, Altmeyer M, Cejka P, Matos J

The CDK1-TOPBP1-PLK1 axis regulates the Bloom's syndrome helicase BLM to suppress crossover recombination in somatic cells

Sci Adv. 2022 Feb 4;8(5):eabk0221.


Yilmaz D, Furst A, Meaburn K, Lezaja A, Wen Y, Altmeyer M, Reina-San-Martin B, Soutoglou E

Activation of homologous recombination in G1 preserves centromeric integrity

Nature. 2021 Dec;600(7890):748-753.


Andreas Panagopoulos, Matthias Altmeyer

When the RAP (80) fades out, you can hear BRCA1 RING

EMBO Rep. 2021 Nov 2:e54116.


Vincent Spegg, Matthias Altmeyer

Biomolecular condensates at sites of DNA damage: More than just a phase

DNA Repair (Amst). 2021 Oct;106:103179.


Porro A, Mohiuddin M, Zurfluh C, Spegg V, Dai J, Iehl F, Ropars V, Collotta G, Fishwick KM, Mozaffari NL, Guérois R, Jiricny J, Altmeyer M, Charbonnier JB, Pearson CE, Sartori AA

FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats

Sci Adv. 2021 Jul 30;7(31):eabf7906.


Lüscher B, Ahel I, Altmeyer M et al.

ADP-ribosyltransferases, an update on function and nomenclature

FEBS J. 2021 Jul 29.


Panagopoulos A, Altmeyer M

The Hammer and the Dance of Cell Cycle Control

Trends Biochem Sci. 2021 Apr;46(4):301-314.



Lezaja A, Panagopoulos A, Wen Y, Carvalho E, Imhof R, Altmeyer M

RPA shields inherited DNA lesions for post-mitotic DNA synthesis

Nat Commun. 2021 Jun 22;12(1):3827


Parnandi N, Rendo V, Cui G, Botuyan MV, Remisova M, Nguyen H, Drané P, Beroukhim R, Altmeyer M, Mer G, Chowdhury D

TIRR inhibits the 53BP1-p53 complex to alter cell-fate programs

Mol Cell. 2021 Jun 17;81(12):2583-2595.e6.


Ghodke I, Remisova M, Furst A, Kilic S, Reina-San-Martin B, Poetsch AR, Altmeyer M, Soutoglou E

AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation

Mol Cell. 2021 Jun 17;81(12):2596-2610.e7.


Michelena J, Pellegrino S, Spegg V, Altmeyer M

Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells

Life Sci Alliance. 2021 Apr 2;4(6):e202101023.


Roeschert I, Poon E, Henssen AG, Garcia HD, Gatti M, Giansanti C, Jamin Y, Ade CP, Gallant P, Schülein-Völk C, Beli P, Richards M, Rosenfeldt M, Altmeyer M, Anderson J, Eggert A, Dobbelstein M, Bayliss R, Chesler L, Büchel G, Eilers M

Combined inhibition of Aurora-A and ATR kinase results in regression of MYCN-amplified neuroblastoma

Nat Cancer. 2021 Mar;2(3):312-326.


Hopp AK, Teloni F, Bisceglie L, Gondrand C, Raith F, Nowak K, Muskalla L, Howald A, Pedrioli PGA, Johnsson K, Altmeyer M, Pedrioli DML, Hottiger MO

Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation

Mol Cell. 2021 Jan 21;81(2):340-354.e5.


Lezaja A and Altmeyer M

Dealing with DNA lesions: When one cell cycle is not

Curr Opin Cell Biol 2020 Dec 10;70:27-36


Rother M.B*, Pellegrino S*, Smith R, Gatti M, Meisenberg C, Wiegant W.W, Luijsterburg M.S, Imhof R, Downs J.A, Vertegaal A.C.O, Huet S, Altmeyer M & van Attikum H
* equal contribution

CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks

2020 Nov 13;11(1):5775


Walser F, Mulder M, Bragantini B, Burger S, Gubser T, Gatti M, Botuyan M.V, Villa A, Altmeyer M, Neri D, Ovaa H, Mer G and Penengo L

Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response

2020 Sep 29;S1097-2765(20)30647-X


Berti M*, Teloni F*, Mijic S, Ursich S, Fuchs J, Palumbieri M.D, Krietsch J, Schmid J.A, Garcin E.B, Gon S, Modesti M, Altmeyer M& Lopes M"
* equal contribution

Sequential role of RAD51 paralog complexes in replication fork remodeling and restart

Nature Communications 2020 Jul 15;11(1):3531.


Gatti M, Imhof R, Huang Q, Baudis M, Altmeyer M
* equal contribution

The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency

Cell Reports 2020 Aug 4;32(5):107985.


Simon A.K, Kummer S, Wild S, Lezaja A, Teloni F, Jozwiakowski S.K, Altmeyer M, Gari K
* equal contribution

The iron–sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation

Life Science Alliance, 2020 Feb 18;3(3):e201900547.


Michelena J, Gatti M, Teloni F, Imhof R, Altmeyer M

Basal CHK1 activity safeguards its stability to maintain intrinsic S-phase checkpoint functions

J Cell Biol. 2019 Jul 31. pii: jcb.201902085


Kilic S, Lezaja A, Gatti M, Bianco E, Michelena J, Imhof R, Altmeyer M

Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments

EMBO J. 2019 Jul 1:e101379


Teloni F, Michelena J, Lezaja A, Kilic S, Ambrosi C, Menon S, Dobrovolna J, Imhof R, Janscak P, Baubec T, Altmeyer M

Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability

Mol Cell. 2019 Feb 21;73(4):670-683.e12

Altmeyer M

Cells take a break when they are TIARed

EMBO Rep. 2019 Jan;20(1). pii: e47403

Klusmann I, Wohlberedt K, Magerhans A, Teloni F, Korbel JO, Altmeyer M, Dobbelstein M

Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication

Proc Natl Acad Sci U S A. 2018 Nov 9

Przetocka S, Porro A, Bolck HA, Walker C, Lezaja A, Trenner A, von Aesch C, Himmels SF, D'Andrea AD, Ceccaldi R, Altmeyer M, Sartori AA

CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress

Mol Cell 2018 Nov 1;72(3):568-582.e6

Michelena J, Lezaja A, Teloni F, Schmid T, Imhof R, Altmeyer M

Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance

Nat Commun. 2018 Jul 11;9(1):2678Editors' Highlights

Lezaja A, Altmeyer M

High Content Imaging für Multidimensionale Zellanalysen

BIOspektrum. 03/2018English Author Version

Altmeyer M

The memory remains

Aging (Albany NY). 2018 Mar 29.

Bosshard M, Aprigliano R, Gattiker C, Palibrk V, Markkanen E, Hoff Backe P, Pellegrino S, Raymond FL, Froyen G, Altmeyer M, Bjørås M, Dianov GL, van Loon B

Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability

Sci Rep. 2017 Nov 8;7(1):15050

Lezaja A, Altmeyer M

Inherited DNA lesions determine G1 duration in the next cell cycle

Cell Cycle. 2017 Oct 5:0

Michelena J, Altmeyer M

Cell cycle resolved measurements of poly(ADP-ribose) formation and DNA damage signaling by quantitative image-based cytometry

Methods Mol Biol. 2017;1608:57-68

Pellegrino S* , Michelena J* , Teloni F, Imhof R, Altmeyer M
* equal contribution

Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin

Cell Rep. 2017 May 30;19(9):1819-1831


Duda H, Arter M, Gloggnitzer J, Teloni F, Wild P, Blanco MG, Altmeyer M, Matos J

A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis

Developmental Cell 39, 740-755 December 19, 2016


Mangerich A, Altmeyer M

Identifying ADP-ribosylation targets by chemical genetics

Translational Cancer Research. 2016


Ochs F, Somyajit K, Altmeyer M, Rask MB, Lukas J, Lukas C

53BP1 fosters fidelity of homology-directed DNA repair

Nat Struct Mol Biol. 2016 Aug;23(8):714-21


Andersson A, Bluwstein A, Kumar N, Teloni F, Traenkle J, Baudis M, Altmeyer M, Hottiger MO

PKCαand HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation

Nucleic Acids Res. 2016 Sep 19;44(16):7630-45

Pellegrino S, Altmeyer M

Interplay between Ubiquitin, SUMO, and Poly(ADP-Ribose) in the Cellular Response to Genotoxic Stress

Front Genet. 2016 Apr 19;7:63


Aguzzi A, Altmeyer M

Phase Separation: Linking Cellular Compartmentalization to Disease

Trends Cell Biol. 2016 Jul;26(7):547-58

Ahuja AK, Jodkowska K, Teloni F, Bizard AH, Zellweger R, Herrador R, Ortega S, Hickson ID, Altmeyer M, Mendez J, Lopes M

A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells

Nat Commun. 2016 Feb 15;7:10660


Teloni F, Altmeyer M

Readers of poly(ADP-ribose): designed to be fit for purpose

Nucleic Acids Res. 2016 Feb 18;44(3):993-1006


Lukas J, Altmeyer M

A lncRNA to repair DNA

EMBO Rep. 2015 Nov;16(11):1413-4



Altmeyer M" , Neelsen KJ, Teloni F, Pozdnyakova I, Pellegrino S, Grøfte M, Rask MB, Streicher W, Jungmichel S, Nielsen ML, Lukas J"
" co-corresponding

Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

Nat Commun 2015;6:8088


Larsen DH, Hari F, Clapperton JA, Gwerder M, Gutsche K, Altmeyer M, Jungmichel S, Toledo LI, Fink D, Rask MB, Grøfte M, Lukas C, Nielsen ML, Smerdon SJ, Lukas J, Stucki M

The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage

Nat Cell Biol. 2014 Aug;16(8):792-803


Engelken J, Altmeyer M, Franklin R

The disruption of trace element homeostasis due to aneuploidy as a unifying theme in the etiology of cancer

BioRxiv. 2014 Jan.


Toledo LI, Altmeyer M, Rask MB, Lukas C, Larsen DH, Povlsen LK, Bekker-Jensen S, Mailand N, Bartek J, Lukas J

ATR prohibits replication catastrophe by preventing global exhaustion of RPA

Cell 2013;155(5):1088-103


Jungmichel S, Rosenthal F, Altmeyer M, Lukas J, Hottiger MO, Nielsen ML

Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses

Mol Cell 2013;52(2):272-85


Altmeyer M, Toledo L, Gudjonsson T, Grøfte M, Rask MB, Lukas C, Akimov V, Blagoev B, Bartek J, Lukas J

The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling

Mol Cell 2013;52(2):206-20


Altmeyer M", Lukas J"
" co-corresponding

Guarding against collateral damage during chromatin transactions

Cell 2013;153(7):1431-4


Altmeyer M", Lukas J"
" co-corresponding

To spread or not to spread--chromatin modifications in response to DNA damage

Curr Opin Genet Dev 2013;23(2):156-65


Altmeyer M

Addicted to PAR? A closer look at PARP inhibitor sensitivity

Cell Cycle. 2012 Nov 1;11(21):3916


Gudjonsson T*, Altmeyer M*, Savic V, Toledo L, Dinant C, Grøfte M, Bartkova J, Poulsen M, Oka Y, Bekker-Jensen S, Mailand N, Neumann B, Heriche JK, Shearer R, Saunders D, Bartek J, Lukas J, Lukas C
* equal contribution

TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes

Cell 2012;150(4):697-709


Asher G, Reinke H, Altmeyer M, Gutierrez-Arcelus M, Hottiger MO, Schibler U

Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding

Cell 2010;142(6):943-53


Toller IM, Altmeyer M, Kohler E, Hottiger MO, Müller A

Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia

Cancer Res. 2010 Jul 15;70(14):5912-22


Messner S*, Altmeyer M*, Zhao H, Pozivil A, Roschitzki B, Gehrig P, Rutishauser D, Huang D, Caflisch A, Hottiger MO
* equal contribution

PARP1 ADP-ribosylates lysine residues of the core histone tails

Nucleic Acids Res. 2010 Oct;38(19):6350-62.


Altmeyer M, Barthel M, Eberhard M, Rehrauer H, Hardt WD, Hottiger MO

Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation

Infect Immun. 2010 Aug;78(8):3420-31


Altmeyer M, Hottiger MO

Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging

Aging (Albany NY). 2009 May 20;1(5):458-69


Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation

Nat Struct Mol Biol. 2009 Sep;16(9):923-9


Messner S, Schuermann D, Altmeyer M, Kassner I, Schmidt D, Schär P, Müller S, Hottiger MO

Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function

FASEB J. 2009 Nov;23(11):3978-89


Altmeyer M, Messner S, Hassa PO, Fey M, Hottiger MO

Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites

Nucleic Acids Res 2009;37(11):3723-38


Haenni SS*, Altmeyer M*, Hassa PO*, Valovka T, Fey M, Hottiger MO
* equal contribution

Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS

BMC Cell Biol. 2008 Jul 21;9:39.


Haenni SS*, Hassa PO*, Altmeyer M*, Fey M, Imhof R, Hottiger MO
* equal contribution

Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation

Int J Biochem Cell Biol. 2008;40(10):2274-83.


Fahrer J, Kranaster R, Altmeyer M, Marx A, Bürkle A

Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length

Nucleic Acids Res. 2007;35(21):e143


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