Publications - SNF Prof. Dr. Matthias Altmeyer

Full list of publications



Michelena J, Gatti M, Teloni F, Imhof R, Altmeyer M
Basal CHK1 activity safeguards its stability to maintain intrinsic S-phase checkpoint functions
J Cell Biol. 2019 Jul 31. pii: jcb.201902085
PubMed Full Text Article



Kilic S, Lezaja A, Gatti M, Bianco E, Michelena J, Imhof R, Altmeyer M
Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments
EMBO J. 2019 Jul 1:e101379
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Teloni F, Michelena J, Lezaja A, Kilic S, Ambrosi C, Menon S, Dobrovolna J, Imhof R, Janscak P, Baubec T, Altmeyer M
Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability
Mol Cell. 2019 Feb 21;73(4):670-683.e12
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Altmeyer M
Cells take a break when they are TIARed
EMBO Rep. 2019 Jan;20(1). pii: e47403
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Klusmann I, Wohlberedt K, Magerhans A, Teloni F, Korbel JO, Altmeyer M, Dobbelstein M
Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication
Proc Natl Acad Sci U S A. 2018 Nov 9
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Przetocka S, Porro A, Bolck HA, Walker C, Lezaja A, Trenner A, von Aesch C, Himmels SF, D'Andrea AD, Ceccaldi R, Altmeyer M, Sartori AA
CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress
Mol Cell 
2018 Nov 1;72(3):568-582.e6
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Michelena J, Lezaja A, Teloni F, Schmid T, Imhof R, Altmeyer M
Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance
Nat Commun. 2018 Jul 11;9(1):2678
PubMed Full Text Article Editors' Highlights


Lezaja A, Altmeyer M
High Content Imaging für Multidimensionale Zellanalysen
BIOspektrum. 03/2018
Full Text Article English Author Version


Altmeyer M
The memory remains
Aging (Albany NY). 2018 Mar 29. doi: 10.18632/aging.101408
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Bosshard M, Aprigliano R, Gattiker C, Palibrk V, Markkanen E, Hoff Backe P, Pellegrino S, Raymond FL, Froyen G, Altmeyer M, Bjørås M, Dianov GL, van Loon B
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability
Sci Rep. 2017 Nov 8;7(1):15050
PubMed Full Text Article



Lezaja A, Altmeyer M
Inherited DNA lesions determine G1 duration in the next cell cycle
Cell Cycle. 2017 Oct 5:0
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Michelena J, Altmeyer M

Cell cycle resolved measurements of poly(ADP-ribose) formation and DNA damage signaling by quantitative image-based cytometry
Methods Mol Biol. 2017;1608:57-68

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Abstract Pellegrino

Pellegrino S, Michelena J, Teloni F, Imhof R, Altmeyer M
Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin

Cell Rep. 2017 May 30;19(9):1819-1831

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Duda H, Arter M, Gloggnitzer J, Teloni F, Wild P, Blanco MG, Altmeyer M, Matos J

A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis 
Developmental Cell 39, 740-755 December 19, 2016
PubMed Full Text Article



Mangerich A, Altmeyer M

Identifying ADP-ribosylation targets by chemical genetics
Translational Cancer Research. 2016 doi: 10.21037/tcr.2016.11.06

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Ochs F, Somyajit K, Altmeyer M, Rask MB, Lukas J, Lukas C
53BP1 fosters fidelity of homology-directed DNA repair
Nat Struct Mol Biol. 2016 Aug;23(8):714-21
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Andersson A, Bluwstein A, Kumar N, Teloni F, Traenkle J, Baudis M, Altmeyer M, Hottiger MO
PKCαand HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation
Nucleic Acids Res. 2016 Sep 19;44(16):7630-45
PubMed Full Text Article



Pellegrino S, Altmeyer M
Interplay between Ubiquitin, SUMO, and Poly(ADP-Ribose) in the Cellular Response to Genotoxic Stress
Front Genet. 2016 Apr 19;7:63
PubMed Full Text Article

TCB Phase Separation


Aguzzi A, Altmeyer M
Phase Separation: Linking Cellular Compartmentalization to Disease
Trends Cell Biol. 2016 Jul;26(7):547-58
PubMed Full Text Article



Ahuja AK, Jodkowska K, Teloni F, Bizard AH, Zellweger R, Herrador R, Ortega S, Hickson ID, Altmeyer M, Mendez J, Lopes M
A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells
Nat Commun. 2016 Feb 15;7:10660
PubMed Full Text Article

NAR2015 Figure1


Teloni F, Altmeyer M
Readers of poly(ADP-ribose): designed to be fit for purpose
Nucleic Acids Res. 2016 Feb 18;44(3):993-1006
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2015 EMBORep


Lukas J, Altmeyer M
A lncRNA to repair DNA
EMBO Rep. 2015 Nov;16(11):1413-4
PubMed Full Text Article

Nat Communs

Altmeyer M, Neelsen KJ, Teloni F, Pozdnyakova I, Pellegrino S, Grøfte M, Rask MB, Streicher W, Jungmichel S, Nielsen ML, Lukas J
Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)
Nat Commun 2015;6:8088

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GA the NBS1


Larsen DH, Hari F, Clapperton JA, Gwerder M, Gutsche K, Altmeyer M, Jungmichel S, Toledo LI, Fink D, Rask MB, Grøfte M, Lukas C, Nielsen ML, Smerdon SJ, Lukas J, Stucki M
The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage
Nat Cell Biol. 2014 Aug;16(8):792-803
PubMed Full Text Article



Engelken J, Altmeyer M, Franklin R
The disruption of trace element homeostasis due to aneuploidy as a unifying theme in the etiology of cancer
BioRxiv. 2014 Jan; doi:
 Full Text Article

Toledo LI, Altmeyer M, Rask MB, Lukas C, Larsen DH, Povlsen LK, Bekker-Jensen S, Mailand N, Bartek J, Lukas J
ATR prohibits replication catastrophe by preventing global exhaustion of RPA
Cell 2013;155(5):1088-103

PubMed Full Text Article


Jungmichel S, Rosenthal F, Altmeyer M, Lukas J, Hottiger MO, Nielsen ML
Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses
Mol Cell 2013;52(2):272-85

PubMed Full Text Article

Altmeyer M, Toledo L, Gudjonsson T, Grøfte M, Rask MB, Lukas C, Akimov V, Blagoev B, Bartek J, Lukas J
The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling
Mol Cell 2013;52(2):206-20

PubMed Full Text Article


Altmeyer M, Lukas J
Guarding against collateral damage during chromatin transactions
Cell 2013;153(7):1431-4

PubMed Full Text Article

Altmeyer M, Lukas J
To spread or not to spread--chromatin modifications in response to DNA damage
Curr Opin Genet Dev 2013;23(2):156-65

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Altmeyer M
Addicted to PAR? A closer look at PARP inhibitor sensitivity
Cell Cycle. 2012 Nov 1;11(21):3916
PubMed Full Text Article

Gudjonsson T, Altmeyer M, Savic V, Toledo L, Dinant C, Grøfte M, Bartkova J, Poulsen M, Oka Y, Bekker-Jensen S, Mailand N, Neumann B, Heriche JK, Shearer R, Saunders D, Bartek J, Lukas J, Lukas C
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes
Cell 2012;150(4):697-709

PubMed Full Text Article


Asher G, Reinke H, Altmeyer M, Gutierrez-Arcelus M, Hottiger MO, Schibler U
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
Cell 2010;142(6):943-53

PubMed Full Text Article




Toller IM, Altmeyer M, Kohler E, Hottiger MO, Müller A
Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia
Cancer Res. 2010 Jul 15;70(14):5912-22
PubMed Full Text Article



Messner S*, Altmeyer M*, Zhao H, Pozivil A, Roschitzki B, Gehrig P, Rutishauser D, Huang D, Caflisch A, Hottiger MO
PARP1 ADP-ribosylates lysine residues of the core histone tails
Nucleic Acids Res. 2010 Oct;38(19):6350-62. *equal contribution
PubMed Full Text Article



Altmeyer M, Barthel M, Eberhard M, Rehrauer H, Hardt WD, Hottiger MO
Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation
Infect Immun. 2010 Aug;78(8):3420-31
PubMed Full Text Article



Altmeyer M, Hottiger MO
Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging
Aging (Albany NY). 2009 May 20;1(5):458-69
PubMed Full Text Article



Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation
Nat Struct Mol Biol. 2009 Sep;16(9):923-9
PubMed Full Text Article



Messner S, Schuermann D, Altmeyer M, Kassner I, Schmidt D, Schär P, Müller S, Hottiger MO
Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function
FASEB J. 2009 Nov;23(11):3978-89
PubMed Full Text Article

Altmeyer M, Messner S, Hassa PO, Fey M, Hottiger MO
Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites
Nucleic Acids Res 2009;37(11):3723-38

PubMed Full Text Article



Haenni SS*, Altmeyer M*, Hassa PO*, Valovka T, Fey M, Hottiger MO
Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS
BMC Cell Biol. 2008 Jul 21;9:39. *equal contribution
PubMed Full Text Article



Haenni SS*, Hassa PO*, Altmeyer M*, Fey M, Imhof R, Hottiger MO
Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation
Int J Biochem Cell Biol. 2008;40(10):2274-83. *equal contribution
PubMed Full Text Article



Fahrer J, Kranaster R, Altmeyer M, Marx A, Bürkle A
Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length
Nucleic Acids Res. 2007;35(21):e143
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