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Department of Molecular Mechanisms of Disease

MSRU Publications

Inglis B, Schwarzenberg P, Klein K, von Rechenberg B, Darwiche S, Dailey HL

Biomechanical duality of fracture healing captured using virtual modeling and validated in ovine bones

Scientific Reports 2022. In Press

 

Ren T, Klein K, von Rechenberg B, Darwiche S, Hannah L. Dailey

Image-Based Radiodensity Profilometry Measures Early Remodeling at the Bone-Callus Interface in Sheep

Biomech Model Mechanobiol. 2022 Jan 8. Epub ahead of print

 

Frese L, Darwiche SE, Gunning ME, Hoerstrup SP, von Rechenberg B, Giovanoli P, Calcagni M

Optimizing large-scale autologous human keratinocyte sheets for major burns-Toward an animal-free production and a more accessible clinical application

Health Sci Rep. 2022 Jan 7;5(1):e449

 

Flück M, Kasper S, Benn MC, Clement Frey F, von Rechenberg B, Giraud MN, Meyer DC, Wieser K, Gerber C

Transplant of Autologous Mesenchymal Stem Cells Halts Fatty Atrophy of Detached Rotator Cuff Muscle After Tendon Repair: Molecular, Microscopic, and Macroscopic Results From an Ovine Model

Am J Sports Med. 2021 Dec;49(14):3970-3980. doi: 10.1177/03635465211052566. Epub 2021 Oct 29. PMID: 34714701; PMCID: PMC8649427

 

Richter H, Bücker P, Martin LF, Dunker C, Fingerhut S, Xia A, Karol A, Sperling M, Karst U, Radbruch A, Jeibmann A

Gadolinium Tissue Distribution in a Large-Animal Model after a Single Dose of Gadolinium-based Contrast Agents

Radiology. 2021 Dec;301(3):637-642. doi: 10.1148/radiol.2021210553. Epub 2021 Sep 21. PMID: 34546128

 

Beltrán Bernal LM, Canbaz F, Darwiche SE, Nuss KMR, Friederich NF, Cattin PC, Zam A

Optical fibers for endoscopic high-power Er:YAG laserosteotomy

J Biomed Opt. 2021 Sep;26(9):095002. doi: 10.1117/1.JBO.26.9.095002. PMID: 34519191; PMCID: PMC8435982

 

Acevedo Rua L, Mumme M, Manferdini C, Darwiche S, Khalil A, Hilpert M, Buchner DA, Lisignoli G, Occhetta P, von Rechenberg B, Haug M, Schaefer DJ, Jakob M, Caplan A, Martin I, Barbero A, Pelttari K

Engineered nasal cartilage for the repair of osteoarthritic knee cartilage defects

Sci Transl Med. 2021 Sep;13(609):eaaz4499. doi: 10.1126/scitranslmed.aaz4499. Epub 2021 Sep 1. PMID: 34516821

 

Schwarzenberg P, Ren T, Klein K, von Rechenberg B, Darwiche S, Dailey HL

Domain-independent simulation of physiologically relevant callus shape in mechanoregulated models of fracture healing

J Biomech. 2021 Mar 30;118:110300. doi: 10.1016/j.jbiomech.2021.110300. Epub 2021 Feb 6. PMID: 33601180

 

Schwarzenberg P, Klein K, Ferguson SJ, von Rechenberg B, Darwiche S, Dailey HL

Virtual mechanical tests out-perform morphometric measures for assessment of mechanical stability of fracture healing in vivo

J Orthop Res. 2021 Apr;39(4):727-738. doi: 10.1002/jor.24866. Epub 2020 Oct 6. PMID: 32970350

 

Paunović N, Bao Y, Coulter FB, Masania K, Geks AK, Klein K, Rafsanjani A, Cadalbert J, Kronen PW, Kleger N, Karol A, Luo Z, Rüber F, Brambilla D, von Rechenberg B, Franzen D, Studart AR, Leroux JC

Digital light 3D printing of customized bioresorbable airway stents with elastomeric properties

Sci Adv. 2021 Feb 3;7(6):eabe9499. doi: 10.1126/sciadv.abe9499. PMID: 33536222; PMCID: PMC7857684

 

Mohsen MO, Balke I, Zinkhan S, Zeltina V, Liu X, Chang X, Krenger PS, Plattner K, Gharailoo Z, Vogt AS, Augusto G, Zwicker M, Roongta S, Rothen DA, Josi R, Costa JJD, Sobczak JM, Nonic A, Brand LA, Nuss K, Martina B, Speiser DE, Kündig T, Jennings GT, Walton SM, Vogel M, Zeltins A, Bachmann MF

A scalable and highly immunogenic virus-like particle-based vaccine against SARS-CoV-2

Allergy. 2022 Jan;77(1):243-257. doi: 10.1111/all.15080. Epub 2021 Sep 20. PMID: 34496033; PMCID: PMC8653185

 

Poupart O, Conti R, Schmocker A, Pancaldi L, Moser C, Nuss KM, Sakar MS, Dobrocky T, Grützmacher H, Mosimann PJ, Pioletti DP

Pulsatile Flow-Induced Fatigue-Resistant Photopolymerizable Hydrogels for the Treatment of Intracranial Aneurysms

Front Bioeng Biotechnol. 2021 Jan 20;8:619858. doi: 10.3389/fbioe.2020.619858. PMID: 33553124; PMCID: PMC7855579

 

Klein K, Schweizer T, Siwy K, Lechmann B, Karol A, Zinkernagel A, von Rechenberg B, Achermann Y, Darwiche SE

Establishment of a localized acute implant-associated Staphylococcus aureus bone infection model in sheep

Pathog Dis. 2021 Jul 2;79(6):ftab032. doi: 10.1093/femspd/ftab032. PMID: 34124751

 

Feusi O, Karol A, Fleischmann T, von Rechenberg B, Bouaicha S, Werner CM, Jentzsch T

Platelet-rich plasma as a potential prophylactic measure against frozen shoulder in an in vivo shoulder contracture model

Archives of Orthopaedic and Trauma Surgery. 2020 Oct 19:1-0

 

Cambria E, Heusser S, Scheuren AC, Tam WK, Karol AA, Hitzl W, Leung VY, Müller R, Ferguson SJ, Wuertz-Kozak K

TRPV4 mediates cell damage induced by hyperphysiological compression and regulates COX2/PGE2 in intervertebral discs

JOR Spine. 2021 May 6;4(3):e1149. doi: 10.1002/jsp2.1149. PMID: 34611585; PMCID: PMC8479521

 

Levinson C, Cavalli E, von Rechenberg B, Zenobi-Wong M, Darwiche SE

Combination of a Collagen Scaffold and an Adhesive Hyaluronan-Based Hydrogel for Cartilage Regeneration: A Proof of Concept in an Ovine Model

Cartilage. 2021 Dec;13(2_suppl):636S-649S. doi: 10.1177/1947603521989417. Epub 2021 Jan 29. PMID: 33511860; PMCID: PMC8721621

 

Schwarzenberg P, Ren T, Klein K, von Rechenberg B, Darwiche S, Dailey HL

Domain-independent simulation of physiologically relevant callus shape in mechanoregulated models of fracture healing

Journal of Biomechanics. 2021 Mar 30;118:110300

 

Frese L, Darwiche SE, von Rechenberg B, Hoerstrup SP, Giovanoli P, Calcagni M

Thermal conditioning improves quality and speed of keratinocyte sheet production for burn wound treatment

Cytotherapy. 2021 Jun;23(6):536-547. doi: 10.1016/j.jcyt.2021.01.006. Epub 2021 Mar 6. PMID: 33685808

 

Laurent A, Abdel-Sayed P, Grognuz A, Scaletta C, Hirt-Burri N, Michetti M, de Buys Roessingh AS, Raffoul W, Kronen P, Nuss K, von Rechenberg B, Applegate LA, Darwiche SE

Industrial Development of Standardized Fetal Progenitor Cell Therapy for Tendon Regenerative Medicine: Preliminary Safety in Xenogeneic Transplantation

Biomedicines. 2021 Apr 3;9(4):380. doi: 10.3390/biomedicines9040380. PMID: 33916829; PMCID: PMC8066015

 

Laurent A, Abdel-Sayed P, Ducrot A, Hirt-Burri N, Scaletta C, Jaccoud S, Nuss K, Roessingh ASB, Raffoul W, Pioletti D, Rechenberg BV, Applegate LA, Darwiche S

Development of Standardized Fetal Progenitor Cell Therapy for Cartilage Regenerative Medicine: Industrial Transposition and Preliminary Safety in Xenogeneic Transplantation

Biomolecules. 2021 Feb 9;11(2):250. doi: 10.3390/biom11020250. PMID: 33572428; PMCID: PMC7916236

 

Kuenzler MB, Nuss K, Karol A, Schär MO, Hottiger M, Raniga S, Kenkel D, von Rechenberg B, Zumstein MA

Neer Award 2016: reduced muscle degeneration and decreased fatty infiltration after rotator cuff tear in a poly(ADP-ribose) polymerase 1 (PARP-1) knock-out mouse model

J Shoulder Elbow Surg. 2017 May;26(5):733-744

 

Gerber C, Meyer DC, Flück M, Valdivieso P, von Rechenberg B, Benn MC, Wieser K

Muscle Degeneration Associated With Rotator Cuff Tendon Release and/or Denervation in Sheep

Am J Sports Med. 2017 Mar;45(3):651-658

 

Mumme M, Steinitz A, Nuss KM, Klein K, Feliciano S, Kronen P, Jakob M, von Rechenberg B, Martin I, Barbero A, Pelttari K

Regenerative Potential of Tissue-Engineered Nasal Chondrocytes in Goat Articular Cartilage Defects

Tissue Eng Part A. 2016 Nov;22(21-22):1286-1295

 

Ernst S, Stübinger S, Schüpbach P, Sidler M, Klein K, Ferguson SJ, von Rechenberg B

Comparison of two dental implant surface modifications on implants  with same macrodesign: an experimental study in the pelvic sheep model

Clin Oral Implants Res. 2015 Aug;26(8):898-908

 

Richter H, Plecko M, Andermatt D, Frigg R, Kronen PW, Klein K, Nuss K, Ferguson SJ, Stöckle U, von Rechenberg B

Dynamization at the near cortex in locking plate osteosynthesis by means of dynamic locking screws: an experimental study of transverse tibial osteotomies in sheep

J Bone Joint Surg Am. 2015 Feb 4;97(3):208-15

 

Mallik AS, Nuss K, Kronen PW, Klein K, Karol A, von Rechenberg B, Rüfenacht DA, Wanke I, Kulcsar Z

A new-generation, low-permeability flow diverting device for treatment of saccular aneurisms

Eur Radiol 2014; 24(1):12-8

 

Plecko M, Lagerpusch N, Andermatt D, Frigg R, Koch R, Sidler M, Kronen P, Klein K, Nuss K, Bürki A, Ferguson SJ, Stoeckle U, Auer JA, von Rechenberg B

The dynamisation of locking plate osteosynthesis by means of dynamic locking screws (DLS)-an experimental study in sheep

Injury. 2013 Oct;44(10):1346-57

 

Klein K, Zamparo E, Kronen PW, Kämpf K, Makara M, Steffen T, von Rechenberg B

Bone augmentation for cancellous bone- development of a new animal model

BMC Musculoskelet Disord. 2013 Jul 2;14:200

 

Nuss K, Gedet P, Bürki A, Ferguson SJ, Stoeckle U, Auer JA, von Rechenberg B

The influence of different osteosynthesis configurations with locking compression plates (LCP) on stability and fracture healing after an oblique 45° angle osteotomy

Injury 2012; 43(7):1041-51

 

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